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Innovative new sensors, such as a recently developed crowding sensor for osmolarity (Cuevas-Velazquez et al., Reference Cuevas-Velazquez, Vellosillo, Guadalupe, Schmidt, Yu, Moses, Brophy, Cosio-Acosta, Das, Wang, Jones, Covarrubias, Sukenik and Dinneny2021), will allow the experimental integration of stress responses, biomechanics and gene expression

Exploring chemoresistance and metastization potential mitigation strategies with combinatorial approaches with other drugs (such as ATRA) may also improve outcomes in the clinical setting

Although use of these products is generally considered safe and well-tolerated, further research is needed to assess any long-term effects

10.7717/peerj.2584 30 SalminenS.ColladoM

TNF- treatment, for instance, causes sustained downregulation of GPX4, rendering cells more susceptible to ferroptosis [166]