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TBI often involves not just direct biomechanical neural damage, but also significant vascular, hormonal, and immune changes that have long-term effects

More help Essentiality of the Key Events The essentiality of KEs can only be assessed relative to the impact of manipulation of a given KE (e.g., experimentally blocking or exacerbating the event) on the downstream sequence of KEs defined for the AOP

Region-specific expression of NMDA receptor GluN2C subunit in parvalbumin-positive neurons and astrocytes: analysis of GluN2C expression using a novel reporter model

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

AICAR accumulation leads to decreased one-carbon metabolism gene expression, cell proliferation, and increased global bioenergetic capacity via AMPK activation (12)