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Cain KC, Headstrom P, Jarrett ME, Motzer SA, Park H, Burr RL, et al

2.3.1 Inflammatory cytokines and myocardial suppression During sepsis, macrophages sensing PAMPs via PRRs (e.g., TLR4) activate key signaling pathways such as NF-B and mitogen-activated protein kinase (MAPK), driving the synthesis and release of large quantities of pro-inflammatory cytokines (TNF-, IL-1, IL-6) (3638)

Subsequently, these bacteria are phagocytosed and neutralized by the oxygen present in hemoglobin

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