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Tetrandrine citrate suppresses breast cancer via depletion of glutathione peroxidase 4 and activation of nuclear receptor coactivator 4-mediated ferritinophagy

Targeted cancer therapy including tyrosine kinase inhibitors (e.g., gefetinib, erlotinib) and aromatase inhibitors (e.g., anastrozole, letrozole and exemestane) have shown toxicities and low clinical efficacy, thus necessitating the use of combination therapy [56]

Genetic predisposition to Hg toxicity A variety of studies in animals (Aten, et al., 1992

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The trend of zinc binding to -synuclein is in unison with the observed effects