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441 In postmortem samples of the human brain, several transcriptional regulators are dysregulated within the DR, including transcription-related elements (such as EGR1, TOB1, and CSDA), which bind to genes to stimulate their expression directly or in response to environmental cues, and NRs (NR4A2, NR4A3, THRA, and THRB), which are activated by ligands and regulate translation by targeting genes

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Annu Rev Physiol 54:303329 Accessed 8 Apr 2013 Accessed 6 Apr 2013 Hummelen R, Hemsworth J, Reid G (2010) Micronutrients, N -acetyl cysteine, probiotics and prebiotics, a review of effectiveness in reducing HIV progression

Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy

Dysregulation of glutamate metabolism leads to multiple pro-inflammatory responses