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d , Counterflow transport of [ 3 H]GSSG into WT or 2YA-mutant SLC33A1 reconstituted liposomes preloaded with 10 mM unlabelled GSSG, followed by incubation with 20 M [ 3 H]GSSG for 40 min

Flavonoids (e.g., quercetin) and phenolic acids (e.g., salvianolic acid B) play pivotal roles in early-stage ALD by directly scavenging reactive oxygen species (ROS) and activating the Nrf2 pathway, thereby blocking lipid peroxidation and mitochondrial dysfunction (Yue et al., 2021)

- The depletion of cysteine resulted in a decrease in glutathione levels and an increase in Fe2+, ROS, and lipid peroxides, all of which are recognized markers of ferroptosis

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doi:10.1271/bbb.63.1291 Hwang C, Sinskey AJ, Lodish HF (1992) Oxidized redox state of glutathione in the endoplasmic reticulum