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They demonstrated that this platform elevated extracellular ATP (eATP) levels, which triggered the activation of the P2X7-NLRP3-inflammasome to drive macrophage pyroptosis and potentiated the maturation and antigen capacity of DCs

Zheng et al., 2025), has undergone an evolution in mechanistic understanding from the traditional lipid infiltration theory to a multi-omics regulatory network perspective (Moore et al., 2018)

Macrophages of the vascular wall can collect iron, and iron overload in turn causes macrophages to transition to an anti-inflammatory phenotype, which leads to inflammation, oxidative stress, and increased plaque formation

Additionally, GHK-Cu has anti-inflammatory and antioxidant properties, which help protect the skin from damage and promotes overall skin health