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Upregulation of TNF- , IL-1 , -6, -18, -23 and IFN- in MNPs, mesenchymal and epithelial cells is sustained by NF-kB, JAK/STAT, c-Jun N-terminal kinase (JNK) and p38 kinase signalling pathways [69]

86.2% White, 3.1% Black, 5.0% Asian, 0.5% AI/AN), while ethnicity was reported in only 36/71 trials (n=5015 participants

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The combination of monthly subscription models, lab monitoring fees, and injection supply sales creates multiple revenue touchpoints from each patient