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55 The above studies imply that breast cancers can be classified into subtypes based on their preference for BCAAs metabolism

To further investigate the molecular mechanisms underlying this phenotype, we explored a multi-omics approach, beginning with metabolomics to examine potential disruptions in amino acid metabolism

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Similar to SGLT2i, some glucagon-like peptide 1 receptor agonists (GLP1RA) have demonstrated a reduction of cardiovascular endpoints in clinical trials, including MACE or CV death alone, thus resulting in a similar guideline recommendation as described before for SGLT2i [147148]