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Then DAPA-HF trial (McMurray et al, NEJM 2019) and the EMPEROR-HF trial (Packer et al, NEJM 2020) drew our attention to the benefits of SGLT2i in halting heart failure progression and lowering cardiovascular (CV) mortality in patients with diabetes mellitus as well as without diabetes mellitus

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[3] [4] The only human data for BPC-157 come from a different direction entirely: early-phase clinical trials for inflammatory bowel disease conducted under the Pliva program (designations PL-10, PLD-116, and PL-14736)

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Future studies should prioritize (1) isolating and characterizing the active compounds within these botanicals, (2) elucidating their precise molecular targets (e.g., thyroid peroxidase, sodium-iodide symporter, cytokine signaling pathways), and (3) conducting well-designed controlled clinical trials to rigorously evaluate their safety and efficacy in human patients