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The researchers developed a small molecule inhibitor to block ASAH2 function

Cagrilintide is engineered to have enhanced receptor affinity and a significantly prolonged half-life compared to native amylin, allowing for more sustained biological activity in experimental models

It also probably includes a contribution from antibody-mediated neutralization

Its ability to regulate actin, a critical component of cell structure and movement, makes it uniquely suited for studies involving injury recovery and tissue remodeling

Serum UA levels were considerably lower in patients at risk of developing PD (UA: 261.6 M, controls: 338.7 M) according to a search for blood alterations during the prodromal period of PD (Katunina et al., 2023)