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Furthermore, signs of gastrointestinal toxicity (nausea, vomiting, constipation, diarrhea, abdominal pain) have been observed following oral iron supplementation at different dosages in humans [55]

The limits of passive targeting techniques are highlighted by thorough assessments of nanoparticle delivery efficiency, which have revealed that, on average, less than 1% of the injected nanoparticle dosage penetrates solid tumors [11, 12]