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Studies observed that gut bacteria produce metabolites such as lipopolysaccharides (LPS), and short-chain fatty acids (SCFAs) that are directly associated with the -synuclein aggregation process ( Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, and Helicobacter pylori stimulate TLR4, triggering immune responses that lead to the production of pro-inflammatory cytokines, chemokines, and oxidative factors

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It functions as the bodys primary intracellular antioxidant, working inside cells to neutralize oxidative stress, assist the liver in binding and removing toxins, regulate immune cell activity, and support mitochondrial function

97 Contemporary in vitro and in vivo evidence indicating a potential effect of N-acetylcysteine in IL-6 inhibition may stimulate further research to understand how the drug affects disease outcomes and maximize its benefits with concomitant pharmacotherapy to selectively inhibit the trans-signalling pathway through which IL-6 signals

MOTS-c Explored in research involving metabolic regulation, energy utilization, and cellular adaptation