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Description

We demonstrate that high levels of mut-p53, through binding to NRF2 and impairing its canonical antioxidant activities, directly promote ROS accumulation in cancer cells

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Can Res 68:13691377 Liu E, Wu J, Cao W, Zhang J, Liu W, Jiang X, Zhang X (2007) Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma