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Synthesis of neuronal lipids and production of neurotransmitters: the increase in methylmalonic acid described in the previous point means that myelin cannot be stabilized correctly, as abnormal fatty acids are formed as a result of succinyl-CoA deficiency

Importantly, the disease causing I148M variant was a gain of function for the interaction with ABHD5 and inhibition of lipolysis, and could promote TAG accumulation in an ABHD5-dependent manner (70)

Extending this technology, we have previously demonstrated the application of sagittal organotypic brain slice cultures to model 6-hydroxydopamine (6-OHDA), a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and quinolinic acid-mediated cell death (McCaughey-Chapman and Connor, 2017

Similarly, while niacinamide is generally well-tolerated, individuals with known sensitivities to B-vitamins or nicotinic acid derivatives should exercise caution

Pregnancy Health B12 deficiencies in the early stages of pregnancy increase the risk of neural tube birth defects and low birthweights