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Kung, C.-P., Liu, Q

17 The HPA axis is the most important neuroendocrine stress system, and the cortisol awakening response (CAR) is a core biomarker of HPA axis regulation

Inhibiting immune evasion mechanisms In cancer treatment, inhibiting autophagy can enhance therapeutic efficacy, but it may upregulate PD-L1, leading to tumor immune evasion

HFD high-fat diet mice in the vehicle cohort received three subcutaneous (SC) saline (1 ml/kg) injections/day ( 0930, 1330, 1730 h) and mice in the treatment cohort received three SC injections of the NNMT inhibitor 5-amino-1MQ at a dose of 20 mg/kg/injection for a total dose of 34 mg/kg/day of the parent compound (calculated according to free weight) for 11 days