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It was initially planned to recruit 20 analyzable patients (who completed the two-treatment periods) to have 80% power to detect, with a two-sided test at 0.05 significance level, an absolute decrease in percentage over total target of 10% under the A-dopamine period compared with the control (oral l-dopa-alone treatment) period, by assuming a standard deviation of 15% and a within-patient correlation of 0.5 to account for the crossover design

Consistent with these observations, a study in older workers reported that current NS workers had significantly shorter telomeres than non-shift workers, while former NS workers showed partial recovery of telomere length with increasing time since cessation, suggesting that NS-induced telomere attrition may be at least partially reversible 241

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doi: 10.1007/978-3-030-45328-2_2 18 KalhanSRossiKGrucaLBurkettEO'BrienA