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Wagner, M

Due to the high molecular weight, most of the drugs fail to cross BBB in pharmacologically significant quantities, and thus not pass the initial screening

In conclusion, to achieve ferroptosis-targeted therapy with nanomaterials, the following steps must be achieved: bloodbrain barrier penetration, tumor targeting, and ferroptosis induction

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In this context, based on the variation in Ce +3 / +4 ratio, CeNPs are reported to show SOD, and catalase-like activities (discussed above), however, coated with dextran showed oxidase mimicking properties (Asati et al., 7 M 1 s 1 of CeNPs than 1 10 8 M 1 s 1 of HRP)