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Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood

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The threshold at which this association has been observed is serum levels over 813 pg/mL (600 pmol/L)

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Macrocytic anaemia is frequently brought on by vitamin B12 deficiency, which has also been linked to various neuropsychiatric problems