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Specifically, given the tolerability for substitutions outside of the binding interface, researchers could explore substitutions on the solvent exposed side of the peptide to recruit an E3 ligase to degrade Mdm2/X

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For purposes of this calculation, an MAO is defined as in 42 CFR 422.2 and means a public or private entity organized and licensed by a State as a risk-bearing entity (with the exception of provider-sponsored organizations receiving waivers) that is certified by CMS as meeting the MA contract requirements