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Macrophages can engage glycolysis, glutamine metabolism, or fatty acid oxidation depending on the stimulus, tissue environment, substrate availability, and effector function being performed ( 2.3 Lipid storage Once FFAs are converted to fatty acyl-CoAs, they can be incorporated into complex lipids, including cholesterol esters, diacylglycerols, phospholipids, and triacylglycerols (TAGs)

Importantly, CD38 expression is induced by inflammatory cytokines, endotoxins, interferon, and some nuclear receptors (Figure 3)[38-39, 52]

Other Toxicities: Rates of CRS (60%, mostly low grade) and ICANS (1.1%) were consistent with known Teclistamab data and were manageable

This allows the patient to potentially cover some of the costs through benefits coverage if applicable

This ensures that what is on the label is actually in the bottle