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And if it does, its often recommended to take it again. Its not unusual for patients to repetitively go on shorter courses of the medication four to six weeks throughout the year if melasma is a chronic condition for them, says Dr

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Atherosclerosis 130 , 2936 (1997)

Specifically, the Akt signal pathway directly acts on FoxO3a to reduce its expression, further inhibiting production of autophagy marker LC3B on the collagen matrix, leading to excessive collagen accumulation (Im et al., 2015)