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Even though these methods involve a great amount of effort, especially the large-scale meta-analysis could allow a clearer conclusion with the highest level of evidence and without potential life-threatening antioxidative intervention

Gastroenterology (2006) 131(4):111021

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The researchers found that vitamin D deficiency is common among individuals with SLE (n=69, 75%), and individuals taking hydroxychloroquine had higher 25(OH)D concentrations compared to those who were not taking hydroxychloroquine, which the authors hypothesized may be due to a decreased rate of conversion of 25(OH)D to 1,25(OH) 2 D 59