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The role of EGFR in suppressing oxidative stress markers in an animal model of Parkinsons disease has also been clarified by a recent study, using Lapatinib (LAP), an anti-cancer drug that acts by mediating oxidative stress, with proven neuroprotective effects in case of epilepsy 37 .They observed that LAP restored glutathione/glutathione peroxidase (GSH/GPx) through the suppression of p-EGFR/c-SRC/PKCII/PLC-/ACSL-4 and PTGS2 38

Tallen HH, Moore S, Stein WH: L-cystathionine in human brain

Barrier dysfunction increases epithelial permeability, enabling inflammatory cytokines to penetrate deeper tissues and exacerbate intraepithelial damage