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While the exact cause of Alzheimers disease remains unclear, multiple hypotheses have been proposed to explain its pathogenesis (55)

10.1016/0928-4257(93)90038-u [DOI] [PubMed] [Google Scholar] Sikiric P., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., et al

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In a separate iteration of this experiment, HT-1080 cells were reverse-transfected with non-targeting (control) siRNAs or siRNAs targeting RRM1 and seeded as described above