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Next, the cleavage of GSDMD (gasdermin D) by caspase 1 and caspase 11 to produce the N-terminal fragment of GSDMD (N-GSDMD) is a critical event in the lethal cascade driving infection-associated pyroptotic cell death [118, 119]

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doi: 10.1093/cei/uxac105 123 CamargoLDNRighettiRFde AlmeidaFMDos SantosTMFukuzakiSMartinsNABet al

It is commonly investigated in preclinical research models relating to peptide signalling pathways, cellular communication mechanisms, and broader biological processes involving peptide-mediated activity

doi: 10.1007/s40265-013-0069-4 57 HardingJ