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Protection of dopaminergic cells by urate requires its accumulation in astrocytes

Antioxidants (Basel) (2022) 11:1151

Importantly, by regulating cellular hydroperoxides (and RNS), GPx-1 may protect against oxidative stress, but, in excess, GPx-1 may also have deleterious effects due to a lack of essential cellular oxidants (154, 251) that result in a reductive stress characterized by a lack of oxidants and/or excess reducing equivalents (297) (Fig