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As individuals age, there is a decline in the activity of the GH/IGF-1 axis, leading to lower IGF-1 concentrations and diminished functionality of the IGF-1 signaling pathway (35)

Cuevasanta, E., Moller, M

Hedman CA, Frystyk J, Lindstrm T et al (2004) Residual beta-cell function more than glycemic control determines abnormalities of the insulin-like growth factor system in type 1 diabetes

10.1007/s11357-023-00861-y 121 PiJ.HayesJ

For example, the excessive activation of ferritinophagy, lipophagy, clock autophagy, and CMA can promote ferroptosis by degrading iron proteins, lipid droplets, circadian rhythm regulators, and GPX4, respectively (Honma et al., 2023