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In pilocarpine-induced seizure in mice, administration of lithium at a low dose (10 mg/kg) reduces seizure severity, though a high dose of lithium (40 mg/kg) increases seizure severity (Jiang et al

J Reprod Fertil, 51: 453-456

Lucena MI, Andrade RJ, de la Cruz JP, Rodriguez-Mendizabal M, Blanco E, Snchez de la Cuesta F

Higher-order oligomerization confers even greater advantages: it promotes cooperative and more specific DNA binding, eases coregulator recruitment, and helps organize DNA looping and chromatin remodeling 88,89,90,91,92