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doi: 10.1039/C6QM00289G 435 LimJSimanekEE

Many practitioners recommend using the first-morning urine because it is more concentrated and may yield clearer results

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Decreased RBC lifespan : This has been documented in mice (due to splenic macrophage erythrophagocytosis [Libregts et al 2011]) and cats with inflammation, although the mechanism was not elucidated in cats (Weiss and Kriehbiel 1983)