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Description

In vivo imaging was performed at 2 h and 24 h post-injection via an IVIS imaging system

In the SAM, a similar redox-based antagonism is observed

As anticipated, MS analysis showed co-fractionation of Flag-Strep ASXL1 with other subunits of the PR-DUB BAP1 complex, including BAP1, HCF-1 and FOXK1/2, as well as MLL3 from MLL3/4 complexes (Fig