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Currently, the approved treatment approach remains based on a stepwise conservative strategy, including early multimodal analgesia, epidural or foraminal corticosteroid injections, individualized physical therapy, and decompression and fusion or artificial disc replacement after conservative treatments fail (Murphy et al., 2023

Martn Gimnez VM, de Las HN, Lahera V, Tresguerres JAF, Reiter RJ, Manucha W (2022) Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases