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Results: INT-787 markedly reduced ( P 7 kPa (n = 16 pts) mean LSM values significantly decreased during follow-up (16 18.6 at T0, 10 11.6 at T6, 6 7.1 kPa at T12, p 0.05 for all)

The terms therapeutically effective (or efficacious) amount and similar descriptions such as an amount efficacious for treatment are intended to mean that amount of a pharmaceutical drug that will alleviate the symptoms of the disorder, condition or disease being treated (i.e., disorder, condition or disease associated with DGAT2 activity) in an animal or human

Rescue of mutant CBS activity has been documented by chemical chaperones 34,41 , haem arginate 42 , and proteostasis inhibitors 43 , suggesting a small molecule therapy could be developed 44,45

Therefore, strategies that restore redox balance are essential for preserving oocyte quality during aging