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In particular, pairing of the trigger RNA to an AGO2miRNA complex induces (1) a structural remodelling of the AGO2 protein that arranges the MID, N and PAZ domains for simultaneous engagement by two interlocked ZSWIM8 protomers

3.2 DNA methyltransferase inhibitors in clinical research 3.2.1 Dinucleotide derivant: Guadecitabine Guadecitabine (SGI-110, 5 ) is a dinucleotide derivative of decitabine, which inhibits DNA methylation by the same mechanism of decitabine, but its PK and stability are superior to those of decitabine due to the phosphodiester bond of SGI-110, which can resist the transient degradation of cytidine deaminase

The compound also demonstrates impressive anti-inflammatory properties

Lynch syndrome is an autosomal dominant inherited disorder associated with a high lifetime risk of developing CRC

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