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H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke

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This process thereby downregulates the NF-B pathway, augments Treg differentiation, and suppresses Th17 expansion and inflammatory cytokine release (215, 216)

There is a lag time to reach the desired plasma concentrations at steady-state, and there will be a lag time for plasma concentrations to change in response to a dose change