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Non-communicable diseases and antioxidant-enzyme interaction Medical conditions that are not generally transmissible and are caused by non-infectious agents are referred to as NCDs

Abbreviations MDA: Malondialdehyde GSH: Glutathione ROS: Reactive oxygen species Bax: Bcl-2 associated x Bcl-2: B-cell lymphoma 2 NLRP3: NOD-like receptor protein 3 MOP: Morinda officinalis polysaccharide PD: Parkinsons disease DA: Dopamine MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPP + : 1-Methyl-4-phenylpyridinium -syn: -Synuclein SOD: Superoxide dismutase IBA1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein IL: Interleukin TNF-: Tumor necrosis factor- CCL: CC motif chemokine ligand G-CSF: Granulocyte colony-stimulating factor ASC: Apoptosis-associated speck-like protein Caspase: Cysteinyl aspartate specific proteinase GSDMD: Gasdermin D TH: Tyrosine hydroxylase DN: Dopaminergic neuron MG: Microglia References Abusrair AH, Elsekaily W, Bohlega S (2022) Tremor in Parkinsons disease: from pathophysiology to advanced therapies

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It should be also noted that early upregulation of GSH in the liver of the proline group should plays an important role in the activation of proliferative signaling within 24 h

Beyond iron sensing, FBXL5 harbors a unique redox-sensitive [2Fe-2S] cluster within its C-terminal substrate-binding domain