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Vitamin B12 Cyanocobalamin It is a common but synthetic form of vitamin B12 that is often added to foods, however, the body must use precious energy to convert this form into methylcobalamin

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However, the PREDIMED trial, which is the exception and covered a long period of time, ended after 4.8 median years of follow-up, and showed strong evidence of the benefit of the MedDiet in many areas, resulting in over 350 publications so far according to their website (69)

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Clinical pharmacokinetic studies show that this gut-mediated conversion is highly unreliable, averaging only about 10% absorption and taking up to 9 hours to reach peak blood levels