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In cells, homocysteine is metabolized in three ways :[ref] It can be remethylated to form methionine (requires folate, MTHFR, and vitamin B12, MTR gene or needs betaine, interacting with BHMT and PEMT genes) Can be converted to cysteine (CBS gene, serine and B6 as a cofactor), which is used in the synthesis of glutathione It can be converted to homocysteine thiolactone, which can be a problem at higher levels Lets dig into each of these pathways further: Methylation Cycle: Homocysteine, Methionine, SAMe, and SAH Homocysteine is maintained at a relatively constant level by several mechanisms in the methionine cycle

These effects are typically dose-dependent and reversible upon discontinuation

10.1038/s41577-021-00643-7 Nat

Plasma was collected and stored at 80 C and the PBMC layer was collected into a new 50-ml Falcon tube, resuspended to 50 ml with PBS and centrifuged at 800 g for 5 min at room temperature

I understand that only a certain amount is absorbed as a function of time, but might a second shot, spaced 4 hours later, be helpful