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Importantly, photolabeling studies using the tricyclic isoxazole photoaffinity label [ 125 I]LY475776 suggested that GSH binding on MRP1 is a prerequisite for binding of LY475776 and so comes prior to the drug binding 51

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10.1105/tpc.108.063503 Plant Cell 127 LiY

With the assistance of complexes, such as Drosha/DGCR, Exportin-5/RAN-GTP, and Dicer/TRBP, primary miRNAs (pri-miRNAs) transcribed from the non-coding region of miRNA genes are processed to form mature miRNAs (Fig