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The study showed mechanistically that mtDNA released into the cytosol can bind to NLRP3, triggering its activation and the subsequent production of inflammatory cytokines like IL-1, contributing to inflammation in lung tissues (Nakahira et al., 2015) (Figure 2)

Adv Sci (Weinh) e2411380 Deng Y, Zeng L, Liu H, Zuo A, Zhou J, Yang Y, You Y et al (2024b) Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1

J.HashamA.SundaramN.TomerY

Thyroid Effects Alpha-lipoic acid appears to interfere with the conversion of T4 (thyroxine) to T3 (triiodothyronine), potentially lowering T3 levels

Gene expression studies have demonstrated that MT genes are differentially regulated in response to a variety of HM stresses (Qu et al., 2024)