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D/L-glucose competition experiment To measure the competitive effects of CDr17 with D/L-glucose, the media of M1 macrophages differentiated from RAW264.7 cell was changed into DMEM, no glucose (Gibco) with 10% Heat-Inactivated Fetal Bovine Serum (Gibco) and 1% Penicillin Streptomycin (WELGENE), containing 0, 20, 60 mM of D/L-glucose

Results and discussion Synthesis and characterization of copolymer The Gu, Hb and DSMA monomers were synthesized according to the literature [29, 30]

Conversely, the early-stage autophagy inhibitor 3-MA partially attenuated KU-mediated LC3-II activation

Possible mild discomfort and swelling post-treatment