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Metabolomic profiling A targeted, liquid chromatographyelectrochemical coulometric array (LCECA) metabolomics platform 43 was used to assay metabolites in plasma samples from the three time points, baseline, 4 weeks, and 8 weeks

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As an evolutionary strategy to counteract truncation-induced toxicity resulting from impaired proteostasis, the cellular system employs compensatory responses such as phosphorylation near truncation sites