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AUC-targeted monitoring may offer more direct alignment with cumulative exposure metrics implicated in ototoxic risk but requires additional sampling and dedicated analytical infrastructure

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Trials with high-risk patients may be restricted due to ethics for treatments that are known or expected to be effective, and they increase difficulty for recruiting

Global Initiative for Chronic Obstructive Lung Disease (2023)

They work similarly to stimulants, boosting the levels of dopamine and norepinephrine in the brain and improving both attention and impulsivity