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I know its generally said to not take any supplements during fasting, especially prolonged fasting

The answer depends on the form of glutathione and how it is processed and packaged

4,5 Glutathione is amazing to brighten skin for that summer glow were all chasing by deactivating the enzyme tyrosinase, which is what causes darker pigments to develop

However, the endoplasmic reticulum, with GSH:GSSG ratios ranging from 1:1 to 3:1, provides a much more oxidizing environment to allow oxidative protein folding