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The extent of the increase, which seems to be genotype dependent, was about 2-fold at 9 C after 4 months or up to 1.8-fold at 4 C after 7 months 151,152

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Key developments include long-acting GH therapies such as somapacitan and lonapegsomatropin gaining FDA approvals for improved compliance in GH deficiency, shifting from daily injections to weekly administration

Exogenous GH delivers the hormone directly, bypassing the pituitary regulatory mechanisms