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Targeting cell death pathways in intestinal ischemia-reperfusion injury: a comprehensive review

BMB Rep 2018;51:429-36

successfully designed and synthesized Fe 3 O 4 @Au-DEX-CP-FA multifunctional nanoparticles ( Transferrin receptor (TfR) is highly expressed on the surface of various cancer cells, which provides a theoretical basis for TfR-mediated targeted drug delivery by Tf-modified nanoparticles ( In addition, mannose receptors (MR) and EpCAM (epithelial cell adhesion molecules) are also effective targets for CRC treatment ( The surface of NDDS can be conjugated with targeting moieties such as antibodies or ligands to specifically bind overexpressed receptors on target cell surfaces, thereby facilitating drug internalization and avoiding off-target effects