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The results showed that three conserved Cys residues were identified in the members of the GPX family, and three conserved domains, GK(R)V(A/T/P)L(M)L(I)V(I)VNVASR(K/Q/E)CG, ILAFPCNQF and WNFT(E/S/A)KF were found in the GPXs of most plants

When tumor cells undergo ferroptosis or cuproptosis, they release a series of damage-associated molecular patterns (DAMPs), such as high mobility group box 1 (HMGB1), ATP, and calreticulin (CRT) [78]

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