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It is likely that DAT may be regulated by ROS in the form of DA quinonens (Page et al., 1998) and peroxynitrile was found to reduce DAT activity by modulation of Cys342 in IL3 (Park et al., 2002)

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Of note, the possible contribution of the particular counteracting effect on the intravenous dextran- or egg whiteinduced anaphylactoid reaction (Duplancic et al., 2014) should also be considered, although not specifically mentioned in this review

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