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Observational studies examining the association of intravenous thiamin as a monotherapy have mainly looked at its association with lactic acidosis, which commonly occurs in both thiamin deficiency and sepsis, and with mortality

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Moreover, arsenic trioxide, nitrosourea, e.g., busulfan or carmustine, or natural compounds, such as curcumine(-derivates) or piperlongumine, are potent inhibitors of the Trx and Grx systems via inhibition of TrxR, GR, or depletion of GSH [207,208] and inducers of ferroptosis [208-211]