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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Ferrari D, Wesselborg S, Bauer MK, Schulze-Osthoff K

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The fact that CysC is sulfenylated in all OAS together with the observed persulfidation of three OAS isoforms may suggest a two-step mechanism in which sulfenylation precedes persulfidation, i.e., when sulfenic acids react with H 2 S

Despite the absence of pGSH1 -driven URA3 expression in the pURA3-URA3 strain, cultivation in the presence of 5-FOA again gave a significant, ~ 50% increase in GSH level (Figure S4B)